Black pepper extract has a positive effect on absorption of nutrients from the intestine. This effect is known as "bioenhancement.". Piperine may be useful for people who suffer from conditions that cause malabsorption of nutrients and people suffering from malnutrition. Black pepper has been used for centuries to treat gastrointestinal distress, inflammation, pain and other disorders.17

Many people don't get enough of this nutrient. While the body uses sunlight to make vitamin D, it cannot make enough if you live in northern climates or don't spend much time in the sun. This vitamin supports healthy cardiovascular function and inflammatory response. It helps maintain normal blood levels of calcium and phosphorus, which strengthen bones. It helps form bones and teeth. Supplementing with this vitamin can reduce the number of non-spinal fractures.

DMAE Bitartrate is also known as Deanol. Deanol is a precursor to the neurotransmitter choline. This is a naturally occurring compound in the brain. The various neurotransmitters play an important role in brain function and cognitive acuity and affect everything from how happy you feel to how much mental energy you have. In addition, DMAE has even been found to possibly have antiaging effects, especially on the skin, when used as a topical gel.13​ DMAE can be a beneficial supplement for a greater overall sense of well-being.

 Through a process involving an enzyme called nitric oxide synthase, L-arginine is converted to nitric oxide in the innermost lining of the arteries known as the endothelium. L-Arginine is well known to promote vasodilation during exercise or hypercholesterolemia (Definition:​ condition of very high levels of cholesterol in the blood).18​ Vasodilation is hindered by this condition and L-arginine has been found to promote smooth muscle relaxation through nitric oxide production.4

L-Tyrosine: Tyrosine can be found in nuts, eggs, dairy products, meats, fish, beans, oats and wheat. Tyrosine is an amino acid and is commonly used for depression, sleep deprivation, chronic fatigue syndrome and as an appetite suppressant. Tyrosine is used to improve mental alertness. What has been found in research studies is that one of the main effects of L-tyrosine that have been reported are acute effects in preventing a decline in cognitive function in response to physical stress.22

Rhodiola rosea herb grows in the Arctic regions of eastern Siberia. Russians have been drinking rhodiola tea for centuries as an energy booster and Russian and Chinese scientists have researched the benefits of Rhodiola root for several decades. The root has a reputation for stimulating the nervous system, enhancing work performance, decreasing fatigue, and reducing high altitude sickness. This herb has been categorized as an adaptogen by Russian researchers due to its observed ability to increase resistance to a variety of chemical, biological, and physical stressors. The adaptogenic, cardiopulmonary protective, and central nervous system activities of rhodiola rosea root have been attributed primarily to its ability to influence levels and activity of monoamines and opioid peptides such as beta-endorphins. Interestingly, in smaller doses the herb is believed to be more stimulating than in larger doses.†